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Metabolism of Benzo[ a ]pyrene to trans -7,8-Dihydroxy-7,8-dihydrobenzo[ a ]pyrene by Recombinant Human Cytochrome P450 1B1 and Purified Liver Epoxide Hydrolase †

✍ Scribed by Shimada, Tsutomu; Gillam, Elizabeth M. J.; Oda, Yoshimitsu; Tsumura, Fujiko; Sutter, Thomas R.; Guengerich, F. Peter; Inoue, Kiyoshi


Book ID
118149915
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
78 KB
Volume
12
Category
Article
ISSN
0893-228X

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## Abstract The potent carcinogen benzo[a]pyrene (B[a]P) and its metabolite B[a]P __trans__‐7, 8‐dihydrodiol (7, 8‐diol) require metabolic activation by the microsomal cytochrome P450s (P450s) to exert several adverse biological effects, including binding to DNA, toxicity, mutagenicity, and carcino