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Regio-selective synthesis of novel 1-tert-butyl-4-nitro-1H-pyrrole-3-carboxylic acid building block

✍ Scribed by Duyan V. Nguyen; Robert A. Schiksnis; Enrique L. Michelotti

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 437 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.09.099

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✦ Synopsis

A convenient, regio-selective synthesis of novel 1-tert-butyl-4-nitro-1H-pyrrole-3-carboxylic acid was developed, utilizing the bulky tert-butyl moiety of 1-tert-butyl-1H-pyrrole to direct selective, un-symmetrical substitutions to the desired 3 and 4 positions.

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