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Regio- and stereoselective synthesis of new spiro-isoxazolidines via 1,3-dipolar cycloaddition

✍ Scribed by Jegham, Nafâa; Bahi, Amira; El Guesmi, Nizar; Kacem, Yakdhane; Ben Hassine, Béchir

Book ID: 124136587
Publisher: Elsevier
Year: 2017
Tongue: English
Weight: 424 KB
Volume: 10
Category: Article
ISSN: 1878-5352
DOI: 10.1016/j.arabjc.2014.05.028

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## Abstract magnified image Asymmetric 1,3‐dipolar cycloadditions of chiral nitrones to 1‐propene‐1,3‐sultone (**1**) were investigated. Chiral nitrones **6a‐e** reacted with sultone **1** in toluene at 90 °C for 24‐36 h to give the corresponding isoxazolidines in moderate yields with high regiose