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Regio- and diastereoselectivity in TiCl4-promoted reduction of 2-aryl-substituted cis-4-methyl-5-trifluoromethyl-1,3-dioxolanes

✍ Scribed by Carlo F. Morelli; Arianna Fornili; Maurizio Sironi; Lavinia Durı̀; Giovanna Speranza; Paolo Manitto


Book ID
104359515
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
263 KB
Volume
13
Category
Article
ISSN
0957-4166

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✍ Dae-Kee Kim; Jongsik Gam; Hun-Taek Kim; Key H. Kim 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 264 KB

The synthesis and in vitro cytotoxicity of cis-(glycolato-O,O')[2-substituted-(4R,5R)-4,5bis(aminomethyl)-l,3-dioxolane]platinum(II) are described. Among them, cis-(glycolato-O,O')[(4R,5R)-4,5-bis(aminomethyl)-2,2-diethyl-l,3-dioxolane]platinum(II) (26) was found to be almost equally cytotoxic to ci