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Regio- and chemoselective addition of alkynyltin reagents to the 2-position of 3-acylpyridines activated by methyl chloroformate: selective synthesis of 2,3-disubstituted 1,2-dihydropyridines

✍ Scribed by Ryohei Yamaguchi; Ei-ichiro Hata; Kiitiro Utimoto

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 254 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)82043-2

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✦ Synopsis

Alkynyltin reagents add to the P-position of 3-acylpyridines activated by methyl chloroformate regio-and chemoselectively to give 2,3_disubstituted 1,2dihydropyridines, whereas alkynyl Grignard reagents suffer from a lack of regioor chemoselectivity.

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