Regeneration of limb abnormalities after ultraviolet irradiation

✍ Scribed by Blum, H. F. ;Butler, E. G. ;Schmidt, S. E.

• Publisher: Wiley (John Wiley & Sons)
• Year: 1958
• Tongue: English
• Weight: 451 KB
• Volume: 52
• Category: Article
• ISSN: 0095-9898
• DOI: 10.1002/jcp.1030520113

✦ Synopsis

It was found in earlier studies that if, after irradiation of the forearms of larvae of the salamander Amblystornct with ultraviolet light, the limbs were amputated in the irradiated region, the regenerating limbs showed a high proportion of abnormalities (Blum et al., '57). It was also observed that by localized irradiation of the elbow region a high proportion of supernumerary appendages could be induced, having a variety of forms ranging from a single digit to a nearly complete hand (Butler and Blum, '55). With this ready means of obtaining abnormal appendages, it has seemed desirable to study regeneration after amputation of the abnormal parts. The primary question is: will the regenerate duplicate the pattern of the abnormality of the part amputated8 The answer, in general, seems negative. Our results indicate, also, that amputation of the irradiated forearm may promote recovery toward the normal.

METHODS AND MATERIAL

There has been no essential change from the methods used in the previous studies referred to above. Since it was desired