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Reevaluation of gastroesophageal reflux disease as a risk factor for laryngeal cancer

✍ Scribed by David O. Francis; Charles Maynard; Ernest A. Weymuller; Gayle Reiber; Albert L. Merati; Bevan Yueh

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 161 KB
Volume: 121
Category: Article
ISSN: 0023-852X
DOI: 10.1002/lary.21165

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Objectives/Hypothesis:

The relationship between gastroesophageal reflux disease (GERD) and laryngeal cancer has not been fully elucidated. This case‐control study investigates whether GERD increases the odds of developing these malignancies.

Study Design:

Case‐control study.

Methods:

Rates of GERD among cases of laryngeal cancer identified in the Veterans Health Administration outpatient care files (year 2000–2006) were compared with controls. Cases (N = 14,449) were frequency matched 1:1 with controls. Multivariate logistic regression was used to determine the association between GERD and cancer.

Results:

After adjusting for tobacco and/or alcohol use, there was no association between GERD and laryngeal cancer (adjusted odds ratio, 1.01; 95% confidence interval, 0.92‐1.12, P =.780). Although an association was found when time from GERD diagnosis to malignancy was less than 3 months, it disappeared when this period was extended further.

Conclusions:

In this population, there was no increased risk of laryngeal cancer among patients with GERD. However, in subsite analysis, a possible relationship between GERD and glottic cancer was observed. Reverse causality must be considered in future studies assessing the relationship between reflux and laryngeal cancer to limit misclassification bias. Laryngoscope, 2011

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