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Reed-sternberg cells in bronchial brushings from a patient with Hodgkin's disease

✍ Scribed by Deepa Kasuganti; David Cimbaluk; Paolo Gattuso

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
67 KB
Volume
34
Category
Article
ISSN
8755-1039

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## Abstract There has been substantial advances in our understanding of the nature of the Hodgkin/Reed–Sternberg (H/RS) cell in recent years. There is now compelling evidence that the H/RS cells in the vast majority of cases of classical Hodgkin's disease (CHD) are derived from the B‐cell lineage a

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Hodgkin and Reed-Sternberg cells are considered to represent the malignant fraction in Hodgkin's disease. Several studies have shown that the Hodgkin and Reed-Sternberg cells are chromosomally abnormal, but genetic data about the morphologically normal cell population in Hodgkin's disease are very l

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We re-appraised the cell renewal pattern in Hodgkin's disease (HD), considering that most, though not all, Hodgkinf Reed- ## Sternberg (H-RS) cells exhibit abortive mitoses and that a substantial fraction of these exhibits DNA damage suggestive of imminent or actual cell death. Using combined immu