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Reed-sternberg cells and their cell microenvironment in Hodgkin's disease with reference to macrophage-histiocytes and interdigitating reticulum cells

✍ Scribed by Dr. Antonino Carbone; Riccardo Manconi; Alessandro Poletti; Sandro Sulfaro; Alessandro Menin; Umberto Tirelli; Piero G. Betta; Rachele Volpe


Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
850 KB
Volume
60
Category
Article
ISSN
0008-543X

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## Epstein-Barr virus (EBV) is detected in Hodgkin and Reed-Sternberg (HRS) cells in up to 50% of patients with Hodgkin's disease (HD). HD patients have been reported to express high serum titers against EBV antigens, even prior to the diagnosis of HD. Patients with high serum titers have a poorer