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Reductive O- and N-alkylations. Alternative catalytic methods to nucleophilic substitution

✍ Scribed by Fabienne Fache; Valérie Bethmont; Laurent Jacquot; Marc Lemaire

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
715 KB
Volume
115
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

Different amides have been selectively mono‐N‐alkylated using catalytic heterogeneous palladium and carbonyl compounds as alkylating agents. The same salt free method has been applied to the synthesis of ethers from alcohols. Reaction parameters have been studied in detail and a mechanism is proposed.

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