Catalytic, enantioselective acetate aldo
✍
Robert A. Singer; Mary S. Shepard; Erick M. Carreira
📂
Article
📅
1998
🏛
Elsevier Science
🌐
French
⚖ 393 KB
A catalytic, enantioselective ~i addition reaction of silyl ketene acetals with oq[i--ynals and 3 tool % of a chiral TiffV) complex is described. This process provides access to optically active ~-hydroxy-'l-alkynyl esters in 84-96% yields and 94-97% ee's.