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Reductive cleavages of α, β-alkynyl acetals. New route to optically pure propargylic alcohols

✍ Scribed by Kazuaki Ishihara; Atsunori Mori; Isao Arai; Hisashi Yamamoto


Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
220 KB
Volume
27
Category
Article
ISSN
0040-4039

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Catalytic, enantioselective acetate aldo
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A catalytic, enantioselective ~i addition reaction of silyl ketene acetals with oq[i--ynals and 3 tool % of a chiral TiffV) complex is described. This process provides access to optically active ~-hydroxy-'l-alkynyl esters in 84-96% yields and 94-97% ee's.