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Catalytic, enantioselective acetate aldol additions to α,β-ynals: Preparation of optically active propargylic alcohols

✍ Scribed by Robert A. Singer; Mary S. Shepard; Erick M. Carreira

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
393 KB
Volume
54
Category
Article
ISSN
0040-4020

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✦ Synopsis

A catalytic, enantioselective ~i addition reaction of silyl ketene acetals with oq[i--ynals and 3 tool % of a chiral TiffV) complex is described. This process provides access to optically active ~-hydroxy-'l-alkynyl esters in 84-96% yields and 94-97% ee's.

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