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Reductive Cleavage of Potential Cholinomimetics Thiadiazolidinones: A New Family of Spiro Compounds

✍ Scribed by Ana Martinez; Diana Alonso; Ana Castro; Enrique Gutierrez-Puebla; Josep-Eladí Baños; Albert Badia

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 283 KB
Volume: 2000
Category: Article
ISSN: 1434-193X
DOI: 10.1002/(sici)1099-0690(200002)2000:4<675::aid-ejoc675>3.0.co;2-6

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✦ Synopsis

The design, synthesis and evaluation of a series of 1,2,4-thiadiazolidinones with potential muscarinic receptor binding properties has been performed. During the synthesis of the target compounds, we observed an interesting reductive cleavage of the thiadiazolidinone system which leads to the formation of the novel piperidine spiro triazine heterocycle.

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