Reductive C-alkylation of barbituric acid derivatives with carbonyl compounds in the presence of platinum and palladium catalysts
โ Scribed by Branko S Jursic; Donna M Neumann
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 75 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Effective synthetic procedures for the preparation of mono-and di-C-alkylated barbituric acid derivatives through palladium and platinum catalytic hydrogenation of solutions of barbituric acids (unsubstituted, N-mono, and N,N%-disubstituted barbituric acids) and carbonyl compounds (aliphatic and aromatic aldehydes and ketones).
๐ SIMILAR VOLUMES
Acetic acid or ZnC12 promote the palladium-catalyzed selective conjugate reduction of a,S-unsaturated carbonyl compounds with trlbutyltln hydride. Protonrc agents also promote the palladium-catalyzed hydrogenolysls of aryl ally1 ethers and ally1 carbamates.
The regioselectivity of alkoxycarbonylation of 1-arylethanols catalysed by Pdracid systems is very sensitive to the nature of the counter anion of the acid: chloride anion favours branched products while tetrafluoroborate and sulfonates anions favour linear products, the latter ones enhancing also p