Carbonylation reactions: 7. Regioselective synthesis of 2-arylpropionic acids by catalytic carbonylation of styrene derivatives in the presence of palladium compounds: the critical role of the counter anion

✍ Scribed by Michel C. Bonnet; Adriano L. Monteiro; Igor Tkatchenko

• Publisher: Elsevier Science
• Year: 1999
• Tongue: English
• Weight: 109 KB
• Volume: 143
• Category: Article
• ISSN: 1381-1169
• DOI: 10.1016/s1381-1169(98)00375-6

✦ Synopsis

The regioselectivity of alkoxycarbonylation of 1-arylethanols catalysed by Pdracid systems is very sensitive to the nature of the counter anion of the acid: chloride anion favours branched products while tetrafluoroborate and sulfonates anions favour linear products, the latter ones enhancing also product yields. Alkoxycarbonylation of styrenes is also sensitive to the nature of the counter anion.