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Reductive alkylation of amino groups in proteins

โœ Scribed by Means, Gary E.; Feeney, Robert E.


Book ID
118014323
Publisher
American Chemical Society
Year
1968
Tongue
English
Weight
968 KB
Volume
7
Category
Article
ISSN
0006-2960

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Bovine pancreatic trypsin inhibitor (BF'TI) was reductively alkylated with 2-methoxy-1-naph-thy1 aldehyde and sodium cyanoborohydride (NaCNBH,). All five possible derivatives, each labeled a t one of the primary amino groups of BPTI, were obtained. The distribution of yields of the various derivativ