Reductive alkylation of 2-methoxybenzoic acid derivatives
β Scribed by James M. Hook; Lewis N. Mander; Michael Woolias
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- French
- Weight
- 231 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
Methylthio-l,4-dihydropyrimidines were obtained by methylation of 2thioxo-4-phenyl-5-methoxycarbonyl-6-methyl-l,2,3,4-tetrahydropyrimidine or its 1-methyl derivative in a neutral medium. The alkylation of tetrahydropyrimidine-2-thiones in the anionic form leads to S-and S,Nmethylation products. Iodo
Meldrum's acid can be reductively alkylated with boraneedimethylamine complex and aldehydes or ketones; boraneetrimethylamine was used with cyclohexanone. Several years ago we noted that Knoevenagel-type products derived from Meldrum's acid (2,2dimethyl-1,3-dioxane-4,6-dione ; isopropylidene malonat
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## Abstract A convenient method is presented using PBH as a safe nonβexplosive reducing agent.