Reduction of O-Acyl Oximes with Sodium Borohydride/Iodine System

✍ Scribed by Barbry, Didier; Champagne, Philippe

• Book ID: 111917471
• Publisher: Taylor and Francis Group
• Year: 1995
• Tongue: English
• Weight: 177 KB
• Volume: 25
• Category: Article
• ISSN: 0039-7911
• DOI: 10.1080/00397919508015484

✦ Synopsis

O-acyl derivatives of aldoximes and ketoximes are reduced in good yields to the corresponding amines with sodium borohydride-iodine system.

Recent paper1 on the reduction of aromatic oximes with borohydride system prompts us to report our results on the transformation of oximes to amines.

This reaction is widely used and the subject has recently been reviewed2. Sodium borohydride does not reduce oximes under ambient conditions but efforts have been made to increase its reactivity with additives. So Periasamy et al3 have recently reported the reduction of carboxytic acids and derivatives using the sodium borohydride / iodine system.