✦ LIBER ✦

Reduction of low-density lipoproteins with dextran sulfate in patients with familial hypercholesterolemia

✍ Scribed by G. Delbert Antwiler; Peter C. Dau; Donn D. Lobdell

Publisher: John Wiley and Sons
Year: 1988
Tongue: English
Weight: 822 KB
Volume: 4
Category: Article
ISSN: 0733-2459
DOI: 10.1002/jca.2920040106

No coin nor oath required. For personal study only.

✦ Synopsis

A novel on-line system for the selective precipitation of low-density lipoprotein (LDL) using dextran sulfate has been devised and tested in four patients with heterozygous familial hypercholesterolemia (type 11). The mean pretreatment serum cholesterol was 410 mg/dl. Plasma was generated by membrane filtration and LDL and VLDL (very-low-density lipoprotein) were completely precipitated with 10-35 mg% dextran sulfate (M, 5,000) in the presence of 55 mM Ca2+. The precipitate was removed by filtration and the excess Ca2* by dialysis. For 41 procedures the mean reduction of plasma solutes was LDL + VLDL 65 % , HDL 23 %, fibrinogen 19 % , albumin 15%, IgG 20%, IgA 19%, IgM 24%. We conclude that dextran sulfate precipitation is an effective method for selective on-line removal of LDL from plasma.

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