A novel on-line system for the selective precipitation of low-density lipoprotein (LDL) using dextran sulfate has been devised and tested in four patients with heterozygous familial hypercholesterolemia (type 11). The mean pretreatment serum cholesterol was 410 mg/dl. Plasma was generated by membran
โฆ LIBER โฆ
Decrease of thyroid hormones in patients with familial hypercholesterolemia during dextran sulphate low-density lipoprotein apheresis
โ Scribed by S. Pintus; Dr. P. Pintus; C. Piras; A. Loviselli; S. Muntoni
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 187 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0733-2459
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โฆ Synopsis
Removal of low-density lipoproteins from plasma by dextran sulfate adsorption (DSA) in FH patients entails a decrease in plasma levels of thyroid hormones (-28.5% and -18.78, respectively, for T3 and T4). This suggests that FH patients have a greater than normal fraction of thyroid hormones bound to lipoproteins, due to their expanded lipoprotein pool.
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