Reduction of aromatic nitro compounds to amines using zinc and aqueous chelating ethers: Mild and efficient method for zinc activation

✍ Scribed by Kumar, Pookot Sunil (author);Lokanatha Rai, Kuriya M. (author)

• Book ID: 111955239
• Publisher: Versita
• Year: 2012
• Tongue: English
• Weight: 297 KB
• Volume: 66
• Category: Article
• ISSN: 0366-6352
• DOI: 10.2478/s11696-012-0195-6

✦ Synopsis

Abstract

A mild, environmentally friendly method for reduction of aromatic nitro group to amine is reported, using zinc powder in aqueous solutions of chelating ethers. The donor ether acts as a ligand and also serves as a co-solvent. Water is the proton source. This procedure is also a new method for the activation of zinc for electron transfer reduction of aromatic nitro compounds. The reduction is accomplished in a neutral medium and other reducing groups remained unaffected. The ethers used are dioxolane, 1,4-dioxane, ethoxymethoxyethane, dimethoxymethane, 1,2-dimethoxyethane, and diglyme.