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Reduction of 4-(Haloalkyl)azetidin-2-ones with LiAlH4 as a Powerful Method for the Synthesis of Stereodefined Aziridines and Azetidines.

โœ Scribed by Willem Van Brabandt; Yves Dejaegher; Robin Van Landeghem; Norbert De Kimpe


Publisher
John Wiley and Sons
Year
2006
Weight
28 KB
Volume
37
Category
Article
ISSN
0931-7597

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## 2-PhenyC4-p-tolylhydrazono-2-oxazoline-5-one (3) was rearranged by the action ofphenols and naphthols into 1,2,4-triazole-5-carboxylic esters (5) that were rearranged further o n reflux in AcOH-ZnCl, into triazolyl ketones (7). Rearrangement of 3 into 1,2,4-triazole derivatives could also be ef