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Reduction of 2-Acylaziridines by Samarium(II) Iodide. An Efficient and Regioselective Route to .beta.-Amino Ketones and Esters

✍ Scribed by Molander, Gary A.; Stengel, Peter J.


Book ID
120801502
Publisher
American Chemical Society
Year
1995
Tongue
English
Weight
258 KB
Volume
60
Category
Article
ISSN
0022-3263

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o!,P-Epoxy esters were rapidly reduced at room temperature to yield P-hydroxy esters with retention of the configurations at the P-carbon atoms by using Sm12-THF-HMPA system in the presence of N,N-dimethylaminoethanol (DMAE). to the synthesis of vinylogous &'-hydroxy esters. The conditions were succ