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Reduction in the frequency of neural tube defects in splotch mice by retinoic acid

✍ Scribed by Kapron-Brás, Carolyn M. ;Trasler, Daphne G.

Book ID
112217502
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
517 KB
Volume
32
Category
Article
ISSN
0040-3709

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## BACKGROUND: The etiology of neural tube defects (NTDs) is multifactorial, with environmental and genetic determinants. Folate supplementation prevents the majority of NTDs, and a polymorphism in methylenetetrahydrofolate reductase (MTHFR) has become recognized as a genetic risk factor. The mech