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Interaction between the splotch mutation and retinoic acid in mouse neural tube defects in vitro

✍ Scribed by Kapron-Brás, Carolyn M. ;Trasler, Daphne G.

Book ID
112217876
Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
756 KB
Volume
38
Category
Article
ISSN
0040-3709

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✍ Haviland, Martha B. ;Essien, Francine B. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 507 KB

## Abstract The Axd mutation in the mouse acts by an unknown mechanism to cause lum‐bosacral open neural tube defects and a variety of tail anomalies. Retinoic acid (RA) plays a number of different physiological and developmental roles and has been shown to affect neurulation in mice and other spec