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Reduction in somatostatin and substance P levels and choline acetyltransferase activity in the cortex and hippocampus of the rat after chronic intracerebroventricular infusion of β-amyloid (1-40)

✍ Scribed by S Nag; B.K Yee; F Tang


Book ID
117502975
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
625 KB
Volume
50
Category
Article
ISSN
0361-9230

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## Abstract Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid β‐peptide (Aβ) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment A