Huperzine A enhances the level of secretory amyloid precursor protein and protein kinase C-α in intracerebroventricular β-amyloid-(1–40) infused rats and human embryonic kidney 293 Swedish mutant cells

Effects of huperzine A on amyloid precur

Effects of huperzine A on amyloid precursor protein processing and β-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells

✍ Ying Peng; Liying Jiang; David Y.W. Lee; Steven C. Schachter; Zhongze Ma; Cynthi 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB

## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (Aβ) sequence, resulting in the release of a secreted fragment of APP (αAPPs) and precluding Aβ generation. In this st