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Reduction in membranous expression of β-catenin and increased cytoplasmic E-cadherin expression predict poor survival in gastric cancer

✍ Scribed by Ramesh, S; Nash, J; McCulloch, P G


Book ID
110002630
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
463 KB
Volume
81
Category
Article
ISSN
0007-0920

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␤-Catenin is a component of the E-cadherin-catenin cell adhesion complex. It plays also a role in intracellular signaling and can function as an oncogene when it binds to the T-cell factor 4 (Tcf4)-binding site in the promoter region of cyclin D1 and transactivates genes after translocation to the n