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Reduction by N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), a calmodulin antagonist, in the number of phorbol ester receptors in mouse skin

โœ Scribed by Hoyoku Nishino; Hirota Fujiki; Masami Suganuma; Takahiko Horiuchi; Akio Iwashima; Takashi Sugimura


Book ID
115757723
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
270 KB
Volume
124
Category
Article
ISSN
0006-291X

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Inhibition of the acrosome reaction of s
โœ Sano, Kiyoshi ๐Ÿ“‚ Article ๐Ÿ“… 1983 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 245 KB

A calmodulin antagonist, W-7 (N-(6-aminohexyl)-5-chloro-l-naphthalenesulfonamide), inhibited induction of the acrosome reaction of sea urchin spermatozoa by egg jelly at 20-50 pM, but W-5 did not. The latter, a chlorine-deficient derivative of W-7, has a lower affinity for calmodulin than does W-7.