𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reduced thrombogenicity of polymers having phospholipid polar groups

✍ Scribed by Ishihara, Kazuhiko ;Aragaki, Runa ;Ueda, Tomoko ;Watenabe, Akihiko ;Nakabayashi, Nobuo

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
530 KB
Volume
24
Category
Article
ISSN
0021-9304

No coin nor oath required. For personal study only.

✦ Synopsis

The thrombogenicity of polymers having a phospholipid polar g r o u p , poly(2methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate (BMA)), was evaluated by a microsphere-column method with attention to the activation and adhesion of platelets on the polymer surface. When citrated platelet-rich plasma (PRP) contacted with the polymers, a large number of platelets adhered and aggregated on poly(BMA). The number of adherent platelets decreased and deformation and aggregation were suppressed with increasing MPC composition. The same tendency was noted when Ca2+-re-added PRP came in contact with the polymers. In the case of poly(MPC-co-BMA) with 0.320 mole fraction of MPC, activation of platelets and formation of fibrin were completely suppressed. Therefore, MPC moieties in the polymer play an important role in the reduction of thrombogenicity of the polymer.

πŸ“œ SIMILAR VOLUMES

Effects of phospholipid adsorption on no
Effects of phospholipid adsorption on nonthrombogenicity of polymer with phospholipid polar group
✍ Ishihara, Kazuhiko ;Oshida, Hiroko ;Endo, Yutaka ;Watanabe, Akihiko ;Ueda, Tomok πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 642 KB

## Abstract Polymers with phospholipid polar groups, 2‐methacryloyloxyethyl phosphorylcholine (MPC) polymers, have excellent nonthrombogenic properties. The effects of adsorption of phospholipids on platelet adhesion and activation on the MPC copolymer with __n__‐butyl methacrylate (BMA) were inves

Synthesis of polymers having a phospholi
Synthesis of polymers having a phospholipid polar group connected to a poly(oxyethylene) chain and their protein adsorption-resistance properties
✍ Kazuhiko Ishihara; Akiko Fujiike; Yasuhiko Iwasaki; Kimio Kurita; Nobuo Nakabaya πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 622 KB

New methacrylates having a phospholipid polar group which was connected to various lengths of poly(oxyethy1ene) chains to form a polymerizable group (MEOnPC) were synthesized. The MEOnPC could polymerize with n-butyl methacrylate (BMA) in ethanol using a conventional radical polymerization technique

Molecular design of functional polymers
Molecular design of functional polymers having amino groups
✍ Tsuruta, Teiji πŸ“‚ Article πŸ“… 1985 πŸ› Wiley (John Wiley & Sons) βš– 539 KB

Three topics on molecular design of functional polymers having amino groups will be discussed. The first topic is on the synthesis of functional isoprene oligomers with one amino end group. The best condition for the synthesis is to seed a small amount of the amino-ended oligomer into a reaction sys

Hemocompatibility of human whole blood o
Hemocompatibility of human whole blood on polymers with a phospholipid polar group and its mechanism
✍ Ishihara, Kazuhiko ;Oshida, Hiroko ;Endo, Yutaka ;Ueda, Tomoko ;Watanabe, Akihik πŸ“‚ Article πŸ“… 1992 πŸ› John Wiley and Sons 🌐 English βš– 580 KB

The hemocompatibility of a polymer containing a phospholipid polar group, poly(2-methacryloyloxyethyl phosphorylcholine (MPC)-co-n-butyl methacrylate(BMA)), with human whole blood was evaluated. When human whole blood without an anticoagulant was contacted with polymers, the blood cell adhesion and

Improved blood compatibility of segmente
Improved blood compatibility of segmented polyurethanes by polymeric additives having phospholipid polar groups. I. Molecular design of polymeric additives and their functions
✍ Ishihara, Kazuhiko ;Tanaka, Shinobu ;Furukawa, Naoya ;Nakabayashi, Nobuo ;Kurita πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 774 KB

To improve the blood compatibility of a segmented polyurethane (SPU), 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer was blended with the SPU. The MPC was copolymerized with cyclohexyl methacrylate (CHMA) or 2ethylhexyl methacrylate (EHMA), and the MPC polymers obtained could be dissolved in