Synthesis of polymers having a phospholipid polar group connected to a poly(oxyethylene) chain and their protein adsorption-resistance properties

✍ Scribed by Kazuhiko Ishihara; Akiko Fujiike; Yasuhiko Iwasaki; Kimio Kurita; Nobuo Nakabayashi

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 622 KB
• Volume: 34
• Category: Article
• ISSN: 0887-624X
• DOI: 10.1002/(sici)1099-0518(19960130)34:2<199::aid-pola6>3.0.co;2-p

✦ Synopsis

New methacrylates having a phospholipid polar group which was connected to various lengths of poly(oxyethy1ene) chains to form a polymerizable group (MEOnPC) were synthesized. The MEOnPC could polymerize with n-butyl methacrylate (BMA) in ethanol using a conventional radical polymerization technique. The unit mole fraction of MEOnPC in the polymer corresponded to that in the feed monomer solution. The MEOnPC polymers were soluble in ethanol, insoluble in water, but swelled in water and became hydrated. On the surface of a poly(BMA) membrane coated with MEOnPC, the phosphorylcholine groups of the MEOnPC unit present were determined by x-ray photoelectron spectroscopy. As a fundamental evaluation for biomedical materials, adsorption of one of the plasma proteins, fibrinogen, on acrylic beads coated with the MEOnPC polymers was evaluated. The amount of fibrinogen adsorbed on the MEOnPC polymer was smaller than that on the original acrylic beads, poly(BMA) and poly(2-hydroxyethyl methacrylate). The increase in the MEOnPC unit mole fraction in the polymer showed more effective protein adsorptionresistant properties.