✦ LIBER ✦

Reduced expression of metabotropic glutamate receptor 2mRNA in T cells of ALS patients

✍ Scribed by Cornelia Poulopoulou; Panagiota Davaki; Vassiliki Koliaraki; Dimitra Kolovou; Ioannis Markakis; Dimitrios Vassilopoulos

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 144 KB
Volume: 58
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.20675

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Metabotropic glutamate receptors alter the vulnerability of neurons to excitotoxic damage and are reported to display abnormal expression in the central nervous system of ALS patients. Using reverse transcriptase polymerase chain reaction, we investigated the mRNA expression of specific metabotropic glutamate receptor subtypes in T lymphocytes of 20 patients with sporadic ALS, compared with healthy age‐matched control subjects and patients with other neurological disorders. The levels of metabotropic glutamate receptor 2 mRNA were markedly reduced, whereas the expression of other subtypes (1b, 3, 8) was similar to control levels. Our findings may provide a reliable peripheral marker of the glutamatergic dysfunction that characterizes ALS. Ann Neurol 2006

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