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Reduced Expression of Insulin-Like Growth Factor-Binding Protein-3 (IGFBP-3) in Squamous Cell Carcinoma Complicating Recessive Dystrophic Epidermolysis Bullosa

✍ Scribed by Mallipeddi, Rajeev; Wessagowit, Vesarat; South, Andrew P.; Robson, Alistair M.; Orchard, Guy E.; Eady, Robin A. J.; McGrath, John A.

Book ID: 110733165
Publisher: Nature Publishing Group
Year: 2004
Tongue: English
Weight: 635 KB
Volume: 122
Category: Article
ISSN: 0022-202X
DOI: 10.1111/j.0022-202x.2004.22525.x

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## Abstract ## Background. Oral squamous cell carcinoma (OSCC) is caused by multiple factors, including carcinogen exposure. Insulin‐like growth factor II mRNA‐binding protein 3 (IMP3) is highly expressed in various cancer cells but is rarely expressed in normal cells. We investigated whether IMP3