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Reduced expression of insulin-like growth factor binding protein-3 and its promoter hypermethylation in human hepatocellular carcinoma

✍ Scribed by Tadashi Hanafusa; Yasuhiro Yumoto; Kazuhiro Nouso; Harushige Nakatsukasa; Toru Onishi; Tatsuya Fujikawa; Mayumi Taniyama; Shinichiro Nakamura; Masayuki Uemura; Yoshitaka Takuma; Eiichiro Yumoto; Toshihiro Higashi; Takao Tsuji


Book ID
117467137
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
400 KB
Volume
176
Category
Article
ISSN
0304-3835

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## Abstract Insulin‐like growth factor binding protein‐3 (IGFBP‐3) is postulated to be a mediator of growth suppression signals. Here, we examined the methylation status of __IGFBP‐3__ to correlate to clinicopathological factors in human cancers. The methylation status of __IGFBP‐3__ was determined