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Reduced effect of morphine in midbrain raphe lesioned rats

✍ Scribed by R. Samanin; W. Gumulka; L. Valzelli

Book ID
118320512
Publisher
Elsevier Science
Year
1970
Tongue
English
Weight
313 KB
Volume
10
Category
Article
ISSN
0014-2999

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πŸ“œ SIMILAR VOLUMES

Effect of midbrain raphe lesion on the a
Effect of midbrain raphe lesion on the antinociceptive action of morphine and other analgesics in rats
✍ R. Samanin; D. Ghezzi; C. Mauron; L. Valzelli πŸ“‚ Article πŸ“… 1973 πŸ› Springer 🌐 English βš– 267 KB

The antinociceptive action of several analgesics was studied by two methods: the hot-plate and the tail compression tests. Lesions of the midbrain raphe, which produce a marked depletion of serotonin in the forebrain, antagonize the analgesic effect of morphine but not that of methadone, meperidine

Effects of intraventriculary injected 6-
Effects of intraventriculary injected 6-OH dopamine or midbrain raphe lesion on morphine analgesia in rats
✍ R. Samanin; S. Bernasconi πŸ“‚ Article πŸ“… 1972 πŸ› Springer 🌐 English βš– 399 KB

Two different techniques were employed to measure morphine analgesia, the hot-plate and the tail compression. An intraventricular injection of 6-hydroxydopamine, which produced a marked decrease of brain noradrenaline and dopamine, strongly potentiated the analgesic effect of morphine. The lesion