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Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior

✍ Scribed by Singh Rajender; Guguluth Pandu; J. D. Sharma; K. P. C. Gandhi; Lalji Singh; Kumarasamy Thangaraj


Publisher
Springer-Verlag
Year
2008
Tongue
German
Weight
196 KB
Volume
122
Category
Article
ISSN
0937-9827

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The human androgen receptor (AR) gene possesses 2 trinucleotide repeats of CAG and GGN in exon 1. The CAG repeat corresponds to a polyglutamine tract in the N-terminal region of the receptor, that affects its transcriptional efficiency. The GGN repeat codifies for a polyglycine tract, and affects th

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## Abstract Changes in the length of a polymorphic trinucleotide (CAG) repeat in the androgen receptor (AR) gene, which may lead to altered transactivation of the AR gene, have been implicated to play a role in the pathogenesis of several forms of endocrine cancer and certain reproductive disorders