Reduced CAG repeats length in androgen receptor gene is associated with violent criminal behavior
β Scribed by Singh Rajender; Guguluth Pandu; J. D. Sharma; K. P. C. Gandhi; Lalji Singh; Kumarasamy Thangaraj
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- German
- Weight
- 196 KB
- Volume
- 122
- Category
- Article
- ISSN
- 0937-9827
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The human androgen receptor (AR) gene possesses 2 trinucleotide repeats of CAG and GGN in exon 1. The CAG repeat corresponds to a polyglutamine tract in the N-terminal region of the receptor, that affects its transcriptional efficiency. The GGN repeat codifies for a polyglycine tract, and affects th
## Abstract Changes in the length of a polymorphic trinucleotide (CAG) repeat in the androgen receptor (AR) gene, which may lead to altered transactivation of the AR gene, have been implicated to play a role in the pathogenesis of several forms of endocrine cancer and certain reproductive disorders