Redox Activation of p21 Cip1/WAF1/Sdi1 : A Multifunctional Regulator of Cell Survival and Death
โ Scribed by O'Reilly, Michael A.
- Book ID
- 120407841
- Publisher
- Mary Ann Liebert
- Year
- 2005
- Tongue
- English
- Weight
- 133 KB
- Volume
- 7
- Category
- Article
- ISSN
- 1523-0864
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Many tumour therapies act by inducing a cellular damage response pathway mediated by the tumour suppressor protein p53. Alternative outcomes of p53 induction include apoptosis or transient cell-cycle arrest, both thought to require the transcriptional activity of wild-type p53. Current research high
WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet