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Redox Activation of p21 Cip1/WAF1/Sdi1 : A Multifunctional Regulator of Cell Survival and Death

โœ Scribed by O'Reilly, Michael A.


Book ID
120407841
Publisher
Mary Ann Liebert
Year
2005
Tongue
English
Weight
133 KB
Volume
7
Category
Article
ISSN
1523-0864

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet