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Multiple pathways control cell growth and transformation: overlapping and independent activities of p53 and p21Cip1/WAF1/Sdi1

✍ Scribed by Cox, Lynne S.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 91 KB
Volume: 183
Category: Article
ISSN: 0022-3417
DOI: 10.1002/(sici)1096-9896(199710)183:2<134::aid-path960>3.0.co;2-d

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✦ Synopsis

Many tumour therapies act by inducing a cellular damage response pathway mediated by the tumour suppressor protein p53. Alternative outcomes of p53 induction include apoptosis or transient cell-cycle arrest, both thought to require the transcriptional activity of wild-type p53. Current research highlights the action of a p53-activated gene, p21 Cip1/WAF1/Sdi1 , which encodes a cyclin-kinase inhibitor important in mediating p53-dependent cell-cycle arrest, while programmed cell death in response to DNA damage requires transcriptionally active p53 but not activation of p21 Cip1/WAF1/Sdi1 . This review examines the roles of p53 and p21 Cip1/WAF1/Sdi1 in controlling cell proliferation, in the light of a new study on expression of p53 and p21 Cip1/WAF1/Sdi1 in squamous cell carcinoma of the larynx. 1997 John Wiley & Sons, Ltd.

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