✦ LIBER ✦

Redesigning Enzyme Topology by Directed Evolution

✍ Scribed by MacBeath, G.

Book ID: 121159233
Publisher: American Association for the Advancement of Science
Year: 1998
Tongue: English
Weight: 538 KB
Volume: 279
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.279.5358.1958

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Enzyme engineering: rational redesign ve

Enzyme engineering: rational redesign versus directed evolution

✍ Ridong Chen 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 25 KB

Directed enzyme evolution

✍ Edgardo T Farinas; Thomas Bulter; Frances H Arnold 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 237 KB

Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary method

Optimising enzyme function by directed e

Optimising enzyme function by directed evolution

✍ Paul A Dalby 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 138 KB

Redesigning enzyme structure by site-dir

Redesigning enzyme structure by site-directed mutagenesis: tyrosyl tRNA synthetase and ATP binding

✍ Winter, Greg; Fersht, Alan R.; Wilkinson, Anthony J.; Zoller, Mark; Smith, Micha 📂 Article 📅 1982 🏛 Nature Publishing Group 🌐 English ⚖ 448 KB

Directed evolution of enzyme catalysts

✍ Olga Kuchner; Frances H. Arnold 📂 Article 📅 1997 🏛 Elsevier Science 🌐 English ⚖ 821 KB

Milestones in directed enzyme evolution

✍ Haiyan Tao; Virginia W Cornish 📂 Article 📅 2002 🏛 Elsevier Science 🌐 English ⚖ 106 KB

Directed evolution has now been used for over two decades as an alternative to rational design for protein engineering. Protein function, however, is complex, and modifying enzyme activity is a tall order. We can now improve existing enzyme activity, change enzyme selectivity and evolve function de