𝔖 Bobbio Scriptorium
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Redesign of catalytic center of an enzyme: aspartic to serine proteinase

✍ Scribed by Takuji Tanaka; Rickey Y. Yada

Book ID
116289127
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
392 KB
Volume
323
Category
Article
ISSN
0006-291X

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## Abstract Calculating the electrostatic potential around the Ser–His–Asp catalytic triad in serine proteinases the very important substituent effect of the buried aspartate is revealed. It is found that the strong Coulomb field of this distant but charged side chain considerably enhances the nucl

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The following FTIR difference spectra were studied: (pepsin) minus (Asp 215 or Asp 32 modified pepsin), (pepsin / pepstatin) minus (the modified pepsin / pepstatin), (at 40ЊC incubated pepsin / substrate) minus (pepsin / substrate at 4ЊC), and (at 40ЊC incubated pepsin / substrate) minus (EPNP modif