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Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts

✍ Scribed by Giorgos Panoutsakopoulos; Nikos Pandis; Ioannis Kyriazoglou; Pelle Gustafson; Fredrik Mertens; Nils Mandahl

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
133 KB
Volume
26
Category
Article
ISSN
1045-2257

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✦ Synopsis

Aneurysmal bone cyst (ABC) is a benign bone lesion for which no previous cytogenetic data exist. We describe the finding of clonal chromosome aberrations in three tumors; two had a t(16;17)(q22;p13) as the sole anomaly, and the third had a del(16)(q22) as the only change. These findings show that somatic mutations contribute to the development of ABC and furthermore indicate that bands 16q22 and 17p13 may harbor genes of importance in this process.

πŸ“œ SIMILAR VOLUMES

t(10;16)(q22;p13) and MORF-CREBBP fusion
t(10;16)(q22;p13) and MORF-CREBBP fusion is a recurrent event in acute myeloid leukemia
✍ JosΓ© L. Vizmanos; MarΓ­a J. LarrΓ‘yoz; Idoya Lahortiga; Filomena FloristΓ‘n; Carmen πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 159 KB

## Abstract Recently, it was shown that t(10;16)(q22;p13) fuses the __MORF__ and __CREBBP__ genes in a case of childhood acute myeloid leukemia (AML) M5a, with a complex karyotype containing other rearrangements. Here, we report a new case with the __MORF__‐__CREBBP__ fusion in an 84‐year‐old patie