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Recurrent pyogenic infections in individuals with absence of the second component of complement

✍ Scribed by Hugh A. Sampson; Andreas M. Walchner; Patricia J. Baker

Publisher
Springer
Year
1982
Tongue
English
Weight
815 KB
Volume
2
Category
Article
ISSN
0271-9142

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A critical role for complement in the regulation of self tolerance has been proposed to explain the strong association between complement deficiency and autoimmunity. To elucidate the role of the classical pathway of complement in the maintenance of B cell tolerance, C1qdeficient (C1qa-/-) mice were