Cytogenetic analyses were performed on 223 breast carcinomas, of which 60% contained homogeneously staining regions (hsr), an intrachromosomal cytogenetic feature of gene amplification. The precise hsr localization could be determined for 123 hsr from 72 cases. The juxtacentromeric region of chromos
Recurrent homogeneously staining regions in 8p1 in breast cancer and lack of amplification of POLB, LHRH, and PLAT genes
✍ Scribed by Claude Saint-Ruf; Michèle Gerbault-Seureau; Evani Viegas-Péquignot; Brigitte Zafrani; Bernard Malfoy; Bernard Dutrillaux
- Book ID
- 119104834
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 490 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0165-4608
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A modified comparative genomic hybridization (mCGH) technique was used t o identify and map amplified DNA sequences in six homogeneously staining regions (hsr) from three primary breast carcinomas. Five different chromosomal regions and bands were identified as sites of amplification: 8p I, I7q2 I.
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