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Recurrent High-Grade Glioma

✍ Scribed by Eudocia C. Quant; Jan Drappatz; Patrick Y. Wen; Andrew D. Norden

Book ID: 107559061
Publisher: Springer
Year: 2010
Tongue: English
Weight: 187 KB
Volume: 12
Category: Article
ISSN: 1092-8480
DOI: 10.1007/s11940-010-0078-5

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## Abstract ## BACKGROUND Doxorubicin exhibits high efficacy in malignant glioma cell cultures. Nonetheless, as a standard formulation, doxorubicin has not been used clinically, due to poor penetration of the blood‐brain barrier. Furthermore, doxorubicin is known to induce tumor resistance genes.