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Cystemustine in recurrent high grade glioma

✍ Scribed by X. Durando; E. Thivat; H. Roché; J.O. Bay; J-J. Lemaire; P. Verrelle; M-A. Lentz; J. Chazal; H. Curé; P. Chollet

Publisher
Springer US
Year
2006
Tongue
English
Weight
180 KB
Volume
79
Category
Article
ISSN
0167-594X

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## Abstract ## BACKGROUND Doxorubicin exhibits high efficacy in malignant glioma cell cultures. Nonetheless, as a standard formulation, doxorubicin has not been used clinically, due to poor penetration of the blood‐brain barrier. Furthermore, doxorubicin is known to induce tumor resistance genes.