Recurrence of symptomatic patent ductus arteriosus in extremely premature infants, treated with indomethacin
โ Scribed by Mats Mellander; Bruno Leheup; Daniel P. Lindstrom; Charlotte Palme; Thomas P. Graham Jr.; Mildred T. Stahlman; Robert B. Cotton
- Book ID
- 119460760
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 455 KB
- Volume
- 105
- Category
- Article
- ISSN
- 1097-6833
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๐ SIMILAR VOLUMES
Sixteen premature infants were treated with indomethacin, either orally or intravenously, in order to close a symptomatic patent ductus arteriosus requiring mechanical ventilation. Positive effect was obtained in 4 of the 10 orally treated patients and in 1 of the 6 with intravenous administration.
Central blood flow (CBF) was estimated by an intravenous 133-xenon technique in six preterm infants before and after administration of indomethacin for closure of patent ductus arteriosus. CBF fell in all infants (range 12%-40%), the mean fall was 24% (P less than 0.005). Though none of the infants