𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Rectal versus oral absorption of codeine phosphate in man

✍ Scribed by Frits Moolenaar; Germ Grasmeijer; Jan Visser; Dirk K. F. Meijer

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
237 KB
Volume
4
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Rectal absorption of codeine phosphate from various dosage forms was studied in man. The rectal dosage forms included aqueous solutions and fatty suppositories. A comparison was made with an orally administered solution. The plasma concentrations of codeine were measured by means of HPLC analysis after a single dose of 60 mg codeine phosphate in a cross‐over study in 7 volunteers. Compared with oral dosing rectal absorption from an aqueous solution or a fatty suppository produced an almost identical plasma concentration profile with similar interindividual variations. Comparing the absorption rate characteristics it appeared that rectal absorption from an alkaline solution containing codeine phosphate proceeded significantly (P < 0·05) more rapid than after oral dosing. No essential difference in bioavailability was observed between the various rectal and oral dosage forms.

📜 SIMILAR VOLUMES

First-pass elimination of salicylamide i
First-pass elimination of salicylamide in man following oral and rectal administration
✍ A. G. de Boer; D. D. Breimer; J. M. Gubbens-Stibbe; A. Bosma 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB 👁 2 views

In order t o study the avoidance of hepatic first-pass elimination following rectal administration, 500 mg of salicylamide (SAM) were given orally and rectally to man. Plasma SAM concentrations were measurable following oral administration, but following rectal administration SAM concentrations were

Plasma concentrations and bioavailabilit
Plasma concentrations and bioavailability of propranolol by oral, rectal and intravenous administration in man
✍ Edison Cid; Fernando Mella; Leonardo Lucchini; Martín Cárcamo; José Monasterio 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 368 KB 👁 2 views

Eight normal male volunteers received 80mg doses of propranolol by the oral and rectal routes and 2.2 mg by intravenous administration in a crossover fashion. Plasma concentrations of propranolol were measured by a gas chromatographic method using an electron capture detector. Individual subject con