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Rectal administration of paracetamol: a comparison of a solution and suppositories in adult volunteers

✍ Scribed by Koll�ffel, W. J. ;Driessen, F. G. W. H. M. ;Goldhoorn, P. B.

Publisher
Springer
Year
1996
Tongue
Dutch
Weight
487 KB
Volume
18
Category
Article
ISSN
1573-739X

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✦ Synopsis

Biological availability BiologiCal equivalence Chromatography, high Paracetamol Pharmacokinetics Solutions Suppositories ~aesthesioiogy, Pharmacy, pressure liquid ~o z

M e t h o d s

Study design

We studied 10 healthy adult volunteers, aged 26 to 55 years, 5 male and 5 female. All gave written informed consent and completed the study, which was approved by the local medical ethics committee. They were interviewed by a physician and were all found to be healthy, especially with respect to the gastrointestinal tract. Their weights ranged between 56 and 85 kg, and their heights between 160 and 184 cm. None of them abused drugs or alcohol and fatty suppository was compared with a solution of 60 mg/ml paracet'arnol. Both dosage forms were given as I000 mg , doses to 10 healthy adult volunteers. The solution produced

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