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Plasma concentration profiles after pre-operative rectal administration of a solution of paracetamol in children

✍ Scribed by Koll�ffel, W. J. ;Driessen, F. G. W. H. M. ;Goldhoorn, P. B.

Publisher: Springer
Year: 1996
Tongue: Dutch
Weight: 345 KB
Volume: 18
Category: Article
ISSN: 1573-739X
DOI: 10.1007/bf00417758

No coin nor oath required. For personal study only.

✦ Synopsis

An exploratory study in paediatric surgical patients was performed to describe the behaviour of a rectal solution of paracetamol at 20 mg/kg. Four of six patients were able to complete the study. Peak concentration (C,) and time to peak concentration (t,,& found in the children are comparable to adults studied earlier. After 1.6 hrs (Lax) a peak concentration of 11.7 mg/l (C,,,) was reached. The area under the curve (AUC,J and the mean residence time (MRT) were respectively 48.3 mghr/l and 5.2 hrs. The solution appears promising for further study in daily clinical practise.

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