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Recovery from mitomycin C-induced hemolytic uremic syndrome: A case report

✍ Scribed by Jaap Verwey; Epie Boven; Jan Van Der Meulen; Herbert M. Pinedo

Publisher: John Wiley and Sons
Year: 1984
Tongue: English
Weight: 341 KB
Volume: 54
Category: Article
ISSN: 0008-543X
DOI: 10.1002/1097-0142(19841215)54:12<2878::aid-cncr2820541211>3.0.co;2-m

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✦ Synopsis

Mitomycin C (MMC) is a cytotoxic agent that may induce a hemolytic uremic syndrome (HUS) with severe renal insufficiency. Of all reported patients with terminal renal failure only two survived with chronic hemodialysis. A patient with advanced gastric cancer in complete remission, who developed MMC-induced HUS, is reported; hemodialysis was necessary because of oliguria. Hemolysis subsided, and after addition of captopril renal function recovered partially. The patient is alive 6 months after discontinuation of hemodialysis. Recently she developed brain metastases. Symptoms of hemolysis did not recur. The pathogenesis and treatment of HUS are discussed.

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